People in countries like the U.S. now spend 87% of their time indoors, with research increasingly indicating that building features (e.g., lighting, materials, iconography) can substantially impact human attitudes, behaviors, and health. As part of the Hybrid Physical-Digital Spaces (HPDS) group at https://hpds.stanford.edu/, this research has several thrusts to develop technology that blends digital and physical infrastructure to support various cognitive, physiological, psychological, and social dimensions of occupant wellness.